Expression and activity of beta-site amyloid precursor protein cleaving enzyme in Alzheimer's disease.
Biochem Soc Trans
; 33(Pt 5): 1096-100, 2005 Nov.
Article
en En
| MEDLINE
| ID: mdl-16246054
Several lines of evidence indicate that the Abeta peptide is involved at some level in the pathological process that results in the clinical symptoms of AD (Alzheimer's disease). The N-terminus of Abeta is generated by cleavage of the Met-Asp bond at position 671-672 of APP (amyloid precursor protein), catalysed by a proteolytic activity called beta-secretase. Two 'beta-secretase' proteases have been identified: BACE (beta-site APP-cleaving enzyme) and BACE2. The cause of sporadic AD is currently unknown, but some studies have reported elevated BACE/beta-secretase activity in brain regions affected by the disease. We have demonstrated that robust beta-secretase activity is also detectable in platelets that contain APP and release Abeta. This review considers the current evidence for alterations in beta-secretase activity, and/or alterations in BACE expression, in post-mortem brain tissue and platelets from individuals with AD.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Endopeptidasas
/
Precursor de Proteína beta-Amiloide
/
Enfermedad de Alzheimer
Límite:
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Año:
2005
Tipo del documento:
Article
Pais de publicación:
Reino Unido