Effects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn rats.
Biol Res
; 38(2-3): 225-33, 2005.
Article
en En
| MEDLINE
| ID: mdl-16238101
Neuromuscular blocking agents suppress central respiratory activity through their inhibitory effects on preinspiratory neurons and the synaptic drive from preinspiratory neurons to inspiratory neurons. Central CO2-chemosensitive areas, which partly consist of CO2-excited neurons, in the rostral ventrolateral medulla are thought to provide tonic drive to the central respiratory network and involve cholinergic mechanisms, which led us to hypothesize that neuromuscular blocking agents can inhibit CO2-excited neurons and attenuate respiratory CO2 responsiveness. To test this hypothesis, we used isolated brainstem-spinal cord preparations from newborn rats. The increase of C4 burst frequency induced by a hypercapnic superfusate, i.e. respiratory CO2 responsiveness, was suppressed by the application of neuromuscular blocking agents, either d-tubocurarine (10, 100 microM) or vecuronium (100 microM). These agents (40 microM) also induced hyperpolarization and decreases in firing frequency of CO2-excited neurons in the rostral ventrolateral medulla. Our results demonstrate that neuromuscular blocking agents inhibit CO2-excited tonic firing neurons and attenuate respiratory CO2 responsiveness.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Centro Respiratorio
/
Bulbo Raquídeo
/
Células Quimiorreceptoras
/
Fármacos Neuromusculares no Despolarizantes
Límite:
Animals
Idioma:
En
Revista:
Biol Res
Asunto de la revista:
BIOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Reino Unido