Neurotrophic effects of fibroblast growth factors on peptide-containing neurons in culture from postnatal rat hypothalamus.
Neuroendocrinology
; 55(2): 193-8, 1992 Feb.
Article
en En
| MEDLINE
| ID: mdl-1620287
Basic fibroblast growth factor (bFGF) has been thought to act as a neurotrophic factor during early developmental stages in various brain regions, including the hypothalamus. In the present paper, we have studied the effect of bFGF on peptide-containing neurons cultured from the postnatal (1-3 days and 14 days after birth) rat hypothalamus. The addition of bFGF, or acid FGF (aFGF), to serum-free culture medium increased both survival and neurite growth of growth hormone-releasing factor (GRF)-containing neurons. The potency of bFGF was more than 10 times as great as that of aFGF. Insulin-like growth factor I (IGF-I) did not have any significant effect on the survival of GRF neurons. Further, neither IGF-I nor aFGF modified the survival-promoting effect of bFGF on GRF neurons. bFGF promoted the survival of somatostatin- and vasoactive intestinal polypeptide-containing neurons, too.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neuropéptidos
/
Factor I del Crecimiento Similar a la Insulina
/
Factores de Crecimiento de Fibroblastos
/
Hipotálamo
/
Animales Recién Nacidos
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Neuroendocrinology
Año:
1992
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Suiza