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Anemia is an independent predictor of mortality and immunologic progression of disease among women with HIV in Tanzania.
O'Brien, Megan E; Kupka, Roland; Msamanga, Gernard I; Saathoff, Elmar; Hunter, David J; Fawzi, Wafaie W.
Afiliación
  • O'Brien ME; Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. meobrien@hsph.harvard.edu
J Acquir Immune Defic Syndr ; 40(2): 219-25, 2005 Oct 01.
Article en En | MEDLINE | ID: mdl-16186741
OBJECTIVES: To examine the association of anemia with mortality and disease progression among a cohort of women with HIV in Dar es Salaam, Tanzania. METHODS: Time to all-cause death, AIDS-related death, and a 50% decrease in CD4 cell count among 1078 HIV-positive pregnant women enrolled in a clinical trial of vitamin supplementation from 1995-2003. RESULTS: Adjusted models showed that anemia was associated with an increased risk of all-cause mortality (relative hazard [RH]: 2.06, 95% CI: 1.52 to 2.79 for moderate anemia and RH: 3.19, 95% CI: 2.23 to 4.56 for severe anemia) and AIDS-related mortality (RH: 2.21, 95% CI: 1.53 to 3.19 for moderate anemia and RH: 3.47, 95% CI: 2.25 to 5.33 for severe anemia), independent of CD4 cell count, World Health Organization clinical stage, age, pregnancy, vitamin supplementation, and body mass index. Anemia was also associated with a more rapid decline in CD4 counts, measured as time to a 50% drop in CD4 cell count from baseline. Erythrocyte characteristics suggestive of iron deficiency were also associated with all-cause and AIDS-related death and a 50% decline in CD4 cell count. CONCLUSIONS: Anemia is an independent predictor of mortality and disease progression in this cohort. Screening for anemia, coupled with prevention and treatment efforts, should be included in HIV care initiatives, particularly those that target women.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Anemia Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans País/Región como asunto: Africa Idioma: En Revista: J Acquir Immune Defic Syndr Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2005 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Buscar en Google
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Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Anemia Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans País/Región como asunto: Africa Idioma: En Revista: J Acquir Immune Defic Syndr Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2005 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos