The effects of Lactobacillus-fermented milk on lipid metabolism in hamsters fed on high-cholesterol diet.
Appl Microbiol Biotechnol
; 71(2): 238-45, 2006 Jun.
Article
en En
| MEDLINE
| ID: mdl-16172889
The objective of this study was to evaluate the effects of local Lactobacillus strains (NTU 101 and 102) on cholesterol-lowering effects in vivo. Thirty male hamsters were housed, divided into five groups, and fed on a cholesterol diet (5 g/kg diet) to induce hypercholesterolemia. Milk fermented by Lactobacillus paracasei subsp. paracasei NTU 101, Lactobacillus plantarum NTU 102, and Lactobacillus acidophilus BCRC 17010 was administrated for this study. After treatment with different fermented milk, blood was taken and liver was removed for the determination of lipoproteins, including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride. Lactobacilli and bifidobacteria decreased (10(5)) in the control group; when hamsters were fed on fermented milk, the number of lactobacilli (10(7)-10(8)) and bifidobacteria (10(5)-10(7)) was increased. Serum and liver total cholesterol levels were significantly reduced by about 26.4, 23.5, and 30.1% and by about 17.7, 15.9, and 13.4% when hamsters were given fermented milk. However, serum HDL-C and LDL-C were also reduced. The results of this study showed that the hypocholesterolemic effect of local Lactobacillus strains was attributed to its ability to lower serum and liver total cholesterol levels. Thus, local Lactobacillus strains could significantly increase probiotic count.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Colesterol en la Dieta
/
Productos Lácteos Cultivados
/
Hipercolesterolemia
/
Lactobacillus
Límite:
Animals
Idioma:
En
Revista:
Appl Microbiol Biotechnol
Año:
2006
Tipo del documento:
Article
Pais de publicación:
Alemania