The use of riboflavin and metalloporphyrins in cytochrome P-450 content in Wistar rats.
Artif Cells Blood Substit Immobil Biotechnol
; 33(3): 271-8, 2005.
Article
en En
| MEDLINE
| ID: mdl-16152692
Phototherapy is commonly used for the treatment of neonatal jaundice. Riboflavin is a photosensitizer that generates singlet oxygen, which promotes bilirubin photodecomposition. Metalloporphyrins are also effective photosensitizers. The effect of a combined dosing regimen of riboflavin and metalloporphyrins was studied, with the aim of increasing the efficiency of the phototherapeutic treatment of hyperbilirubinemia. It was envisaged that riboflavin and the metalloporphyrins, by promoting the photodecomposition of bilirubin, would thereby lead to a reduction of the toxic side effects associated with phototherapy. The results shows that a phototherapeutic treatment, in which riboflavin and metalloporphyrins were co-administered, was effective in reducing Heme Oxygenase activity. However, a comprehensive study of the possible side effects of metalloporphyrin treatment in the wavelength under consideration is essential prior to utilizing these compounds for any clinical applications.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fotoquimioterapia
/
Riboflavina
/
Sistema Enzimático del Citocromo P-450
/
Ictericia Neonatal
/
Hígado
/
Metaloporfirinas
Límite:
Animals
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
Artif Cells Blood Substit Immobil Biotechnol
Asunto de la revista:
BIOTECNOLOGIA
/
TRANSPLANTE
Año:
2005
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Reino Unido