Role of insulin in the progression of ovarian sex cord stromal tumors in rats.
J Cancer Res Clin Oncol
; 131(11): 751-7, 2005 Nov.
Article
en En
| MEDLINE
| ID: mdl-16136354
PURPOSE: This study examined the effect of insulin on sex cord stromal tumors in the rat. METHODS: Sex cord stromal tumors were induced by transplantation of ovaries under the splenic capsule of ovariectomized rats (Lewis-inbred). These tumors were then transplanted into new inbred rats. Hyperglycemic conditions were induced by treatment with streptozotocin (STZ, which selectively destroyed pancreatic islet cells) and hypoglycemic conditions by treatment with a subcutaneously implanted insulin pump (Alzet). The animals were killed 28, 56, and 84 days later. Tumor growth, animal weight, food and water consumption, and serum concentrations of glucose, FSH, LH, and estradiol were measured. RESULTS: Treatment with STZ and insulin with osmotic Alzet pumps induced continuous hypoglycemic and hyperglycemic conditions, respectively. No significant influence of the hypoglycemic or hyperglycemic status on tumor growth was measured during the first 28 and 56 days. Eighty-four days after transplantation and substitution of 1 or 2 IU/100 g body weight/d insulin, there was a significant stimulation of tumor growth (2.2-fold and 2.7-fold, respectively). In hyperglycemic animals (treated with STZ), no influence on tumor growth was found in comparison with the controls. CONCLUSION: This study confirms that hyperinsulinemic conditions contribute to the progression of tumors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biomarcadores de Tumor
/
Tumores de los Cordones Sexuales y Estroma de las Gónadas
/
Hiperinsulinismo
/
Insulina
Límite:
Animals
Idioma:
En
Revista:
J Cancer Res Clin Oncol
Año:
2005
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Alemania