Evaluation of chemical and antiviral properties of essential oils from South American plants.
Antivir Chem Chemother
; 16(4): 247-51, 2005.
Article
en En
| MEDLINE
| ID: mdl-16130522
The essential oils of seven aromatic plants from Córdoba, San Luis and San Juan Provinces (Argentina) were isolated by steam distillation and analysed by a gas chromatography/mass spectrometry technique. The oils were screened for cytotoxicity and in vitro inhibitory activity against herpes simplex virus type 1 (HSV-1), dengue virus type 2 (DENV-2) and Junin virus (JUNV) by a virucidal test. The oils showed a variable virucidal action according to the virus. The better relationship between cytotoxicity and antivirus action was observed with the essential oils of Heterothalamus alienus and Buddleja cordobensis against JUNV, with virucidal concentration 50% (VC50) values of 44.2 and 39.0 ppm and therapeutic indices (cytotoxicity to virucidal activity ratio) of 3.3 and 4.0, respectively. The inhibitory action was exerted by a direct interaction of virions with the oils. Virions inactivated with B. cordobensis and H. alienus essential oil were not affected in their ability to bind to the host cell. The therapeutic indices shown by these essential oils in toto were very modest, but given the complexity of their chemical composition the future identification of the precise active principle may allow the elimination of cytotoxic components and increase the selectivity of the effective compound.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Aceites de Plantas
/
Virus Junin
/
Herpesvirus Humano 1
/
Virus del Dengue
Tipo de estudio:
Prognostic_studies
País/Región como asunto:
America do sul
/
Argentina
Idioma:
En
Revista:
Antivir Chem Chemother
Asunto de la revista:
QUIMICA
/
TERAPIA POR MEDICAMENTOS
/
VIROLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Argentina
Pais de publicación:
Reino Unido