Your browser doesn't support javascript.
loading
Mutations in the rpoB gene of rifampicin-resistant Mycobacterium tuberculosis clinical isolates from Lithuania.
Bakonyte, D; Baranauskaite, A; Cicenaite, J; Sosnovskaja, A; Stakenas, P.
Afiliación
  • Bakonyte D; Laboratory of Immunology, Institute of Biotechnology, Vilnius, Lithuania.
Int J Tuberc Lung Dis ; 9(8): 936-8, 2005 Aug.
Article en En | MEDLINE | ID: mdl-16104644
A total of 196 rifampicin (RMP) resistant Mycobacterium tuberculosis isolates were searched for mutations in the cluster I region of the rpoB gene. Seventeen different types of mutations were observed in 184 (93.9%) isolates. The remaining isolates searched also had no mutations in the N-terminal region of this gene. Mutations were most frequently detected at single codons Ser531 (47.4%), His526 (20.9%), and Asp516 (20.4%). Our data indicate that genotypic drug susceptibility assays based on detection of mutations at the specific codons of the rpoB gene should be effective for predicting resistance to RMP and rifabutin and multidrug resistance in Lithuania.
Asunto(s)
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rifampin / Proteínas Bacterianas / Farmacorresistencia Bacteriana / Antibióticos Antituberculosos / Mycobacterium tuberculosis Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Int J Tuberc Lung Dis Año: 2005 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Francia
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rifampin / Proteínas Bacterianas / Farmacorresistencia Bacteriana / Antibióticos Antituberculosos / Mycobacterium tuberculosis Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Int J Tuberc Lung Dis Año: 2005 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Francia