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Increasing seroprevalence of human herpesvirus 8 (HHV-8) with age confirms HHV-8 endemicity in Amazon Amerindians from Brazil.
Cunha, A M G; Caterino-de-Araujo, A; Costa, S C B; Santos-Fortuna, E; Boa-Sorte, N C A; Gonçalves, M S; Costa, F F; Galvão-Castro, B.
Afiliación
  • Cunha AMG; Gonçalo Moniz Research Center/Fiocruz, 121 rua Waldemar Falcão, 40295-001 Salvador, BA, Brazil.
  • Caterino-de-Araujo A; Departments of Clinical Pathology and Internal Medicine, School of Medical Sciences/State University of Campinas (UNICAMP), Brazil.
  • Costa SCB; Immunology Section, Adolfo Lutz Institute, São Paulo, Brazil.
  • Santos-Fortuna E; Departments of Clinical Pathology and Internal Medicine, School of Medical Sciences/State University of Campinas (UNICAMP), Brazil.
  • Boa-Sorte NCA; Immunology Section, Adolfo Lutz Institute, São Paulo, Brazil.
  • Gonçalves MS; Bahiana Medical School, Bahiana Foundation for the Development of Sciences, Salvador, Brazil.
  • Costa FF; Gonçalo Moniz Research Center/Fiocruz, 121 rua Waldemar Falcão, 40295-001 Salvador, BA, Brazil.
  • Galvão-Castro B; Gonçalo Moniz Research Center/Fiocruz, 121 rua Waldemar Falcão, 40295-001 Salvador, BA, Brazil.
J Gen Virol ; 86(Pt 9): 2433-2437, 2005 Sep.
Article en En | MEDLINE | ID: mdl-16099900
Human herpesvirus 8 (HHV-8) seroprevalences were determined in two isolated Amazon Amerindian tribes, according to age, gender and familial aggregation. Plasma and serum samples obtained from 982 Amazon Amerindians (664 Tiriyó and 318 Waiampi) were tested for antibodies against lytic and latent HHV-8 antigens by using 'in-house' immunofluorescence assays. Overall, HHV-8 seroprevalence was 56.8 % (57.4 % in the Tiriyó tribe and 55.7 % in the Waiampi tribe). Seroprevalence was independent of gender and increased linearly with age: it was 35.0 % among children aged 2-9 years, 51.4 % in adolescents (10-19 years), 72.9 % in adults and 82.3 % in adults aged >50 years. Interestingly, 44.4 % of children under 2 years of age were HHV-8-seropositive. No significant differences in seroprevalence between tribes and age groups were detected. It is concluded that HHV-8 is hyperendemic in Brazilian Amazon Amerindians, with vertical and horizontal transmission during childhood, familial transmission and sexual contact in adulthood contributing to this high prevalence in these isolated populations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Indígenas Sudamericanos / Infecciones por Herpesviridae / Herpesvirus Humano 8 / Enfermedades Endémicas / Anticuerpos Antivirales Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Gen Virol Año: 2005 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Indígenas Sudamericanos / Infecciones por Herpesviridae / Herpesvirus Humano 8 / Enfermedades Endémicas / Anticuerpos Antivirales Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Gen Virol Año: 2005 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido