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Enterovirus RNA sequences in sera of schoolchildren in the general population and their association with type 1-diabetes-associated autoantibodies.
Moya-Suri, V; Schlosser, M; Zimmermann, K; Rjasanowski, I; Gürtler, L; Mentel, R.
Afiliación
  • Moya-Suri V; Friedrich Loeffler Institute of Medical Microbiology1 and Institute of Pathophysiology2, Ernst Moritz Arndt University of Greifswald, Germany 3Center of Diabetes and Metabolic Disorders, Karlsburg, Germany.
  • Schlosser M; Friedrich Loeffler Institute of Medical Microbiology1 and Institute of Pathophysiology2, Ernst Moritz Arndt University of Greifswald, Germany 3Center of Diabetes and Metabolic Disorders, Karlsburg, Germany.
  • Zimmermann K; Friedrich Loeffler Institute of Medical Microbiology1 and Institute of Pathophysiology2, Ernst Moritz Arndt University of Greifswald, Germany 3Center of Diabetes and Metabolic Disorders, Karlsburg, Germany.
  • Rjasanowski I; Friedrich Loeffler Institute of Medical Microbiology1 and Institute of Pathophysiology2, Ernst Moritz Arndt University of Greifswald, Germany 3Center of Diabetes and Metabolic Disorders, Karlsburg, Germany.
  • Gürtler L; Friedrich Loeffler Institute of Medical Microbiology1 and Institute of Pathophysiology2, Ernst Moritz Arndt University of Greifswald, Germany 3Center of Diabetes and Metabolic Disorders, Karlsburg, Germany.
  • Mentel R; Friedrich Loeffler Institute of Medical Microbiology1 and Institute of Pathophysiology2, Ernst Moritz Arndt University of Greifswald, Germany 3Center of Diabetes and Metabolic Disorders, Karlsburg, Germany.
J Med Microbiol ; 54(Pt 9): 879-883, 2005 Sep.
Article en En | MEDLINE | ID: mdl-16091441
Type 1 diabetes (T1D) is an autoimmune disease linked with genetic factors as well as with environmental triggers, such as virus infections, but the aetiology is still unclear. The authors analysed serum from autoantibody-positive (n=50) and autoantibody-negative (n=50) schoolchildren as well as children newly diagnosed with T1D (n=47; time from diagnosis, median 5 days, interquartile range 1-12 days) for the presence and frequency of enterovirus (EV) and adenovirus sequences. The autoantibody-positive and -negative groups were part of the Karlsburg Type 1 Diabetes Risk Study of a Normal Schoolchild Population, which represents a general population without T1D first-degree relatives. There was no significant seasonality of sampling in any of the three groups investigated. EV RNA sequences were detected in 10 of 50 (20%) autoantibody-positive children and in 17 of 47 (36%) children newly diagnosed with T1D, but only in two of 50 (4%) of the age- and sex-matched controls (P<0.05, P<0.001). Characterization of the EV amplicons by direct sequencing revealed high homology with coxsackievirus B group. For adenovirus we found no data to support an association with T1D. The data support the hypothesis that different enteroviruses may be aetiologically important as a trigger and/or accelerating factor in the process of T1D development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / ARN Viral / Diabetes Mellitus Tipo 1 / Infecciones por Enterovirus Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Med Microbiol Año: 2005 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / ARN Viral / Diabetes Mellitus Tipo 1 / Infecciones por Enterovirus Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Med Microbiol Año: 2005 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido