Cytokine and growth factor production by monocytes/macrophages on protein preadsorbed polymers.
J Biomed Mater Res
; 26(7): 837-50, 1992 Jul.
Article
en En
| MEDLINE
| ID: mdl-1607370
These studies evaluate the effect of biomedical polymers: Biomer, polydimethyl-siloxane (PDMS), polyethylene, expanded polytetrafluoroethylene (ePTFE), Dacron, and the control polystyrene with or without adsorbed proteins IgG, fibrinogen, and fibronectin on the ability of activated human monocytes/macrophages to produce Interleukin 1 Beta (IL-1-B), Interleukin 6 (IL-6), and Tumor Necrosis Factor Alpha (TNF-A). Monocytes/macrophages incubated on biomedical polymers with or without protein preadsorption produce variable levels of IL-1-B, IL-6, and TNF-A dependent on the polymer and adsorbed protein. IL-6 was produced in the greatest quantity and was the most influenced by protein adsorption. ePTFE and PDMS polymers were least stimulating while polystyrene was the most stimulating of monocyte activity. Adsorbed IgG consistently altered the ability of the polymers to activate monocytes/macrophages to produce cytokines. These studies provide important insight into conditions which modulate monocyte/macrophage activity in response to protein preadsorbed biomedical polymers.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polímeros
/
Monocitos
/
Proteínas
/
Interleucina-6
/
Interleucina-1
/
Factor de Necrosis Tumoral alfa
/
Macrófagos
Límite:
Adult
/
Humans
Idioma:
En
Revista:
J Biomed Mater Res
Año:
1992
Tipo del documento:
Article
Pais de publicación:
Estados Unidos