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Water channel activities of Mimosa pudica plasma membrane intrinsic proteins are regulated by direct interaction and phosphorylation.
Temmei, Yusuke; Uchida, Shinichi; Hoshino, Daisuke; Kanzawa, Nobuyuki; Kuwahara, Michio; Sasaki, Sei; Tsuchiya, Takahide.
Afiliación
  • Temmei Y; Department of Chemistry, Faculty of Science and Technology, Sophia University, 7-1 Kioi, Chiyoda-ku, Tokyo 102-8554, Japan.
FEBS Lett ; 579(20): 4417-22, 2005 Aug 15.
Article en En | MEDLINE | ID: mdl-16061230
cDNAs encoding aquaporins PIP1;1, PIP2;1, and TIP1;1 were isolated from Mimosa pudica (Mp) cDNA library. MpPIP1;1 exhibited no water channel activity; however, it facilitated the water channel activity of MpPIP2;1 in a phosphorylation-dependent manner. Mutagenesis analysis revealed that Ser-131 of MpPIP1;1 was phosphorylated by PKA and that cooperative regulation of the water channel activity of MpPIP2;1 was regulated by phosphorylation of Ser-131 of MpPIP1;1. Immunoprecipitation analysis revealed that MpPIP1;1 binds directly to MpPIP2;1 in a phosphorylation-independent manner, suggesting that phosphorylation of Ser-131 of MpPIP1;1 is involved in regulation of the structure of the channel complex with MpMIP2;1 and thereby affects water channel activity.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Plantas / Membrana Celular / Acuaporinas / Mimosa / Proteínas de la Membrana Límite: Animals Idioma: En Revista: FEBS Lett Año: 2005 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Plantas / Membrana Celular / Acuaporinas / Mimosa / Proteínas de la Membrana Límite: Animals Idioma: En Revista: FEBS Lett Año: 2005 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido