Perianal fistulas in Crohn's disease are predominantly colonized by skin flora: implications for antibiotic treatment?
Dig Dis Sci
; 50(7): 1260-3, 2005 Jul.
Article
en En
| MEDLINE
| ID: mdl-16047469
In this study we aimed to determine the microorganisms found in perianal fistulas in Crohn's disease and whether treatment with ciprofloxacin affects these microorganisms. Thirteen patients (males/females, 7/6; median age, 34 years; range, 18-61 years) with fistulas were treated with infliximab, 5 mg/kg intravenously, at weeks 6, 8, and 12 and randomized to double-blind treatment with ciprofloxacin, 500 mg bd (n = 6), or placebo (n = 7) for 12 weeks. Samples were taken at baseline and at weeks 6 and 18. In the ciprofloxacin group 10 different genera of microorganisms were identified, while 13 genera could be identified in the placebo group. Gram-negative enteric floras were present in a small minority. The genera found in patients with perianal fistulas were predominantly gram-positive microorganisms. Therefore, antimicrobial treatment should be directed toward these microorganisms.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Infecciones Bacterianas
/
Enfermedad de Crohn
/
Ciprofloxacina
/
Fístula Rectal
/
Antiinfecciosos
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Dig Dis Sci
Año:
2005
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Estados Unidos