Essential thrombocythemia--clinical features, therapy and follow-up of 12 cases.
Leukemia
; 6 Suppl 3: 138S-140S, 1992.
Article
en En
| MEDLINE
| ID: mdl-1602810
The authors analyzed twelve patients with symptomatic essential throthrombocythemia (E.T.) diagnosed from 1983 to 1991. Haemorrhagic and thrombotic phenomena were the main presenting features. Treatment consisted mostly of alpha-interferon (IFN-alpha 2b) subcutaneously in dosage ranging from 3 to 5 MU/m2 and hydroxyurea (HU) in conventional dosage. A clinical response was seen in seven patients treated with IFN-alpha 2b (4 CR and 2 PR), and in four patients treated with HU (3 CR and 1 PR). No significant side effects were observed. Our findings indicate that IFN-alpha 2b offers a non-leukaemogenic and very promising therapeutic alternative for E.T.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Interferón-alfa
/
Trombocitemia Esencial
/
Hidroxiurea
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Leukemia
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
Año:
1992
Tipo del documento:
Article
País de afiliación:
Portugal
Pais de publicación:
Reino Unido