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Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles.
Miller, John F; Brieger, Michael; Furfine, Eric S; Hazen, Richard J; Kaldor, Istvan; Reynolds, David; Sherrill, Ronald G; Spaltenstein, Andrew.
Afiliación
  • Miller JF; GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. john.6.miller@gsk.com
Bioorg Med Chem Lett ; 15(15): 3496-500, 2005 Aug 01.
Article en En | MEDLINE | ID: mdl-15990305
A novel series of tyrosine-derived HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and two protease inhibitor-resistant viruses. All of the compounds had wild-type antiviral activities that were similar to or greater than several currently marketed HIV protease inhibitors. In addition, a number of compounds in this series were more potent against the drug-resistant mutant viruses than they were against wild-type virus.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Replicación Viral / VIH / Inhibidores de la Proteasa del VIH / Fármacos Anti-VIH / Farmacorresistencia Viral Múltiple Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2005 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Replicación Viral / VIH / Inhibidores de la Proteasa del VIH / Fármacos Anti-VIH / Farmacorresistencia Viral Múltiple Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2005 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido