Nitric oxide synthase activity and endogenous inhibitors in rats recovered from allergic encephalomyelitis.

Teixeira, S A; Varriano, A A; Dias, A A; Martins Porto, R; Muscará, M N

Teixeira, S A; Varriano, A A; Dias, A A; Martins Porto, R; Muscará, M N.

Afiliación

Teixeira SA; Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP 05508-900, Brasil.

Mem Inst Oswaldo Cruz ; 100 Suppl 1: 25-7, 2005 Mar.

Article en En | MEDLINE | ID: mdl-15962095

RESUMEN

We have previously reported that in comparison with normal rats, the presence of experimental allergic encephalomyelitis (EAE) leads to decreased endogenous inhibitory activity (EIA) of Ca2+-dependent nitric oxide synthase (NOS) in both brain and serum, and increased expression of protein 3-nitrotyrosine (NT) in brain. In this work we show that animals recovered from the clinical signs of EAE are not different from controls in terms of either brain NOS activity, EIA of NOS, or NT expression. These results suggest that parallel to the reversal of the disease symptoms, a normalization of the production of nitric oxide and related species occurs.

Asunto(s)

Encéfalo/enzimología; Encefalomielitis Autoinmune Experimental/enzimología; Óxido Nítrico Sintasa de Tipo III/metabolismo; Óxido Nítrico/metabolismo; Animales; Dineínas Citoplasmáticas; Dineínas/metabolismo; Encefalomielitis Autoinmune Experimental/sangre; Masculino; Óxido Nítrico Sintasa de Tipo III/antagonistas & inhibidores; Ratas; Ratas Endogámicas Lew

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Encefalomielitis Autoinmune Experimental / Óxido Nítrico Sintasa de Tipo III / Óxido Nítrico Límite: Animals Idioma: En Revista: Mem Inst Oswaldo Cruz Año: 2005 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil

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