Clomiphene citrate as a new treatment for SUNCT: hormonal manipulation for hypothalamic-influenced trigeminal autonomic cephalalgias.

Rozen, Todd D; Saper, Joel R; Sheftell, Fred D; Dodick, David W

Rozen, Todd D; Saper, Joel R; Sheftell, Fred D; Dodick, David W.

Afiliación

Rozen TD; Michigan Head Pain & Neurological Institute, Dept. Neurology, 3120 Professional Drive, Ann Arbor, MI, USA.

Headache ; 45(6): 754-6, 2005 Jun.

Article en En | MEDLINE | ID: mdl-15953310

RESUMEN

We present a patient with treatment refractory short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) who was found to have low levels of serum testosterone supporting the hypothalamic connection to this trigeminal autonomic cephalalgia. Clomiphene citrate therapy induced a significant elevation of testosterone levels (by its effect on hypothalamic estrogen receptors) and led to a dramatic reduction in SUNCT attacks. Hormonal manipulation may be a treatment strategy for hypothalamic-influenced trigeminal autonomic cephalalgias.

Asunto(s)

Clomifeno/uso terapéutico; Cefalea/tratamiento farmacológico; Moduladores Selectivos de los Receptores de Estrógeno/uso terapéutico; Testosterona/sangre; Enfermedades del Sistema Nervioso Autónomo/complicaciones; Enfermedades de la Conjuntiva/complicaciones; Cefalea/sangre; Cefalea/complicaciones; Humanos; Hipotálamo/metabolismo; Lágrimas/metabolismo; Neuralgia del Trigémino/complicaciones

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testosterona / Clomifeno / Moduladores Selectivos de los Receptores de Estrógeno / Cefalea Límite: Humans Idioma: En Revista: Headache Año: 2005 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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