Microwave-assisted synthesis of N,N'-diaryl cyanoguanidines.

Hamilton, Sean K; Wilkinson, Doug E; Hamilton, Gregory S; Wu, Yong-Qian

Hamilton, Sean K; Wilkinson, Doug E; Hamilton, Gregory S; Wu, Yong-Qian.

Afiliación

Hamilton SK; Department of Research, Guilford Pharmaceuticals, Inc., Baltimore, Maryland 21224, USA.

Org Lett ; 7(12): 2429-31, 2005 Jun 09.

Article en En | MEDLINE | ID: mdl-15932215

RESUMEN

[reaction: see text] A mild, efficient, and high-yielding method for the synthesis of N,N'-diaryl cyanoguanidines from their corresponding thioureas under microwave-assisted conditions is described. A series of cyanoguanidines were synthesized containing both electron-donating and electron-withdrawing substituents. The reactions were facilitated by the use of polar solvents along with moderate temperatures.

Asunto(s)

Guanidinas/síntesis química; Microondas; Catálisis; Estructura Molecular; Sulfuros/síntesis química; Temperatura

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Guanidinas / Microondas Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2005 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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