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Preparation and characterization of a novel pH-sensitive ion exchange resin.
Liu, Hongfei; Zhang, Shu; Nie, Shufang; Zhao, Xin; Sun, Xiyang; Yang, Xingang; Pan, Weisan.
Afiliación
  • Liu H; Department of Pharmaceutics, Shen yang Pharmaceutical University, Shen yang 110016, People's Republic of China. liuhongfei1979@sohu.com
Chem Pharm Bull (Tokyo) ; 53(6): 631-3, 2005 Jun.
Article en En | MEDLINE | ID: mdl-15930772
Methylacrylic acid/styrene cross-linked with divinylbenzene is a novel pH-sensitive ion exchange resin. Microspheres of this resin were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The microspheres showed a pulsatile swelling behavior when the pH of the media changed. The pH-sensitive microspheres were loaded with salbutamol sulfate and the drug-release characteristics were studied under both simulated gastric and intestinal pH conditions. The results obtained showed that the drug release also depended on the pH of the release media.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resinas de Intercambio Iónico Tipo de estudio: Diagnostic_studies Idioma: En Revista: Chem Pharm Bull (Tokyo) Año: 2005 Tipo del documento: Article Pais de publicación: Japón
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resinas de Intercambio Iónico Tipo de estudio: Diagnostic_studies Idioma: En Revista: Chem Pharm Bull (Tokyo) Año: 2005 Tipo del documento: Article Pais de publicación: Japón