Immune response and alteration of pulmonary function after primary human metapneumovirus (hMPV) infection of BALB/c mice.
Vaccine
; 23(36): 4473-80, 2005 Aug 22.
Article
en En
| MEDLINE
| ID: mdl-15927322
Human metapneumovirus (hMPV), a recently identified virus, causes upper and lower respiratory tract diseases. In this study, we show that BALB/c mice inoculated with hMPV exhibited significant morbidity on 1--2 days post-infection, when airway obstruction was found. Increased airway hyper-responsiveness to metacholine was found on day 4 concurrent with lung viral replication. Both IgG1 and IgG2a hMPV-specific antibodies were found in sera, while interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) were found in bronchoalveolar lavage. Lung histology showed parenchymal pneumonia and increased lymphocytic infiltration. We present here an animal model that may be helpful in studying hMPV pathogenesis and evaluating the effects of vaccines.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Paramyxoviridae
/
Metapneumovirus
/
Modelos Animales de Enfermedad
/
Pulmón
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Vaccine
Año:
2005
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Países Bajos