DNA methylation pattern changes during development of a sea urchin.
Biochem J
; 283 ( Pt 3): 751-3, 1992 May 01.
Article
en En
| MEDLINE
| ID: mdl-1590764
Cytosine methylation of developmentally regulated genes of the sea urchin Strongylocentrotus purpuratus was studied by using restriction-endonuclease digestion and Southern blotting. The single-copy bindin gene, the family of five cytoplasmic actin genes and the 400-fold-repeated set of five early histone genes were mostly unmethylated, but some sites exhibited partial methylation that varied throughout development. This shows that in echinoderms the methylation of DNA is not confined to the non-transcribed portion of the genome, as previously believed [Bird, Tagart & Smith (1979) Cell 17, 889-901], and may play a role in transcriptional regulation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Erizos de Mar
/
ADN
/
Regulación de la Expresión Génica
Límite:
Animals
Idioma:
En
Revista:
Biochem J
Año:
1992
Tipo del documento:
Article
Pais de publicación:
Reino Unido