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Structure and biological activity of heparinoid.
Kumar, Neeraj; Bentolila, A; Domb, A J.
Afiliación
  • Kumar N; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar 060-062, India.
Mini Rev Med Chem ; 5(5): 441-7, 2005 May.
Article en En | MEDLINE | ID: mdl-15892686
Heparin is a biogenic anionic charged sulfated polysaccharide that has a range of desired activities including inhibition of tumor metastasis and inhibition of restenosis. However, its clinical use is limited to treating blood-clotting disorders. Anionic macromolecules called heparinoids have been investigated with the objective of developing heparin-like molecules with reduced anti-coagulant activity and selective anti-metastasis and anti-restenosis activity. This mini-review summarizes the synthesis and biological activity of the main synthetic heparinoids reported in the past three decades.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores Enzimáticos / Heparinoides / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Mini Rev Med Chem Asunto de la revista: QUIMICA Año: 2005 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores Enzimáticos / Heparinoides / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Mini Rev Med Chem Asunto de la revista: QUIMICA Año: 2005 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos