PMUT: a web-based tool for the annotation of pathological mutations on proteins.
Bioinformatics
; 21(14): 3176-8, 2005 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-15879453
PMUT allows the fast and accurate prediction (approximately 80% success rate in humans) of the pathological character of single point amino acidic mutations based on the use of neural networks. The program also allows the fast scanning of mutational hot spots, which are obtained by three procedures: (1) alanine scanning, (2) massive mutation and (3) genetically accessible mutations. A graphical interface for Protein Data Bank (PDB) structures, when available, and a database containing hot spot profiles for all non-redundant PDB structures are also accessible from the PMUT server.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Interfaz Usuario-Computador
/
Programas Informáticos
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Proteínas
/
Modelos Moleculares
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Alineación de Secuencia
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Redes Neurales de la Computación
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Análisis de Secuencia de Proteína
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Modelos Químicos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Bioinformatics
Asunto de la revista:
INFORMATICA MEDICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Reino Unido