[Effect of estrogen on the blast transformation of lymphocytes and interleukin-2 production in lupus erythematosus]. / Oestrogen hatása a lymphocyta blastos transformatióra és az interleukin-2 termelésre systemás lupus erythematosusban.
Orv Hetil
; 133(19): 1167-71, 1992 May 10.
Article
en Hu
| MEDLINE
| ID: mdl-1584598
ABSTRACT
PIP: 12 patients with systemic lupus erythematosus (SLE) (8 in the active stage) with an average age of 26 years (17-54) and 20 healthy control subjects (9 were aged 18-49 years and 11 were oral contraceptives [OC] users aged 17-44) were studied to assess the inhibiting effect of estrogen in vitro on phytohemagglutinin (PHA) and Pokeweed (PWM) mitogen induced blast transformation of lymphocytes (lymphoblastic transformation=LBT) gained from periphral blood and simultaneous interleukin-2 (IL-2) production. 8 women were taking Anteovin, 2 Ovidon, and 1 Rigevidon. The average duration of OC use was 5.2 years. 1 SLE patient did not need immunosuppressive treatment, 3 patients received corticosteroid maintenance therapy, and 4 patients were also taking 50 mg of Imuran. In 4 active SLE patients the tests were done before raising the dose of immunosuppressive drugs, and in the case of 2 other patients the administration of 75 mg and 25 mg/die Prednisolone was necessary in addition to 50 mg and 100 mg/die Imuran. LBT decreased significantly in patients and OC users. The LBT values induced by PWM were similar but not significant. The IL-2 production induced by PHA decreased in all 3 groups but not significantly. I1-2 production was 6 E/ml in patients, 5 E/ml in OC users, and 11.5 E/ml in nonusers, but the differences did not prove significant because of wide individual fluctuations. The amount of IL-2 produced by lymphocytes at PWM stimulation was almost the same in all 3 groups with or without estrogen. There was a positive, significant relationship between the extent of LBT and the amount of IL-2 produced in the healthy group of nonusers, it was less solid in the OC users, and in the SLE group trhe low correlation coefficient of .34 suggested the reduction of IL-2 through the inhibition of LBT.
Palabras clave
Biology; Contraception; Contraceptive Agents, Estrogen--side effects; Contraceptive Agents, Female--side effects; Contraceptive Agents--side effects; Contraceptive Methods--side effects; Developed Countries; Diseases; Eastern Europe; Ethinyl Estradiol--side effects; Europe; Family Planning; Hematological Effects; Hemic System; Hungary; Immunity; Immunological Effects; Oral Contraceptives, Combined--side effects; Oral Contraceptives--side effects; Physiology; Systemic Lupus Erythematosus
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Crisis Blástica
/
Interleucina-2
/
Anticonceptivos Hormonales Orales
/
Estrógenos
/
Lupus Eritematoso Sistémico
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
Hu
Revista:
Orv Hetil
Año:
1992
Tipo del documento:
Article
Pais de publicación:
Hungria