HIC1 promoter methylation and 17p13.3 allelic loss in invasive ductal carcinoma of the breast.

Parrella, Paola; Scintu, Marina; Prencipe, Maria; Poeta, Maria Luana; Gallo, Antonietta Pia; Rabitti, Carla; Rinaldi, Monica; Tommasi, Stefania; Paradiso, Angelo; Schittulli, Francesco; Valori, Vanna Maria; Toma, Salvatore; Altomare, Vittorio; Fazio, Vito Michele

Parrella, Paola; Scintu, Marina; Prencipe, Maria; Poeta, Maria Luana; Gallo, Antonietta Pia; Rabitti, Carla; Rinaldi, Monica; Tommasi, Stefania; Paradiso, Angelo; Schittulli, Francesco; Valori, Vanna Maria; Toma, Salvatore; Altomare, Vittorio; Fazio, Vito Michele.

Afiliación

Parrella P; Laboratory of Gene Therapy and Oncology, IRCCS, Casa Sollievo della Sofferenza, Viale Padre Pio, 71013 San Giovanni Rotondo (FG), Italy. pparrella@operapadrepio.it

Cancer Lett ; 222(1): 75-81, 2005 May 10.

Article en En | MEDLINE | ID: mdl-15837543

RESUMEN

The HIC1 gene is a transcriptional regulator commonly methylated in a variety of human cancer. Thirty-three invasive ductal carcinomas of the breast and 21 matched normal breast tissues were analysed for HIC1 promoter methylation, and allelic loss of a 700 kb region spanning the gene locus. At least one genetic or epigenetic abnormality was found in 27 of the carcinomas tested (82%). Promoter methylation was demonstrated in 21 carcinomas (64%), and nine normal tissues (43%), whereas 18 malignant tumors (54%) showed allelic loss. Concomitant loss of heterozigosity and promoter hypermethylation in the region spanning HIC1 was detected in eight carcinomas (24%) suggesting that in this subset of tumors both copies of the gene are functionally lost. These observations support a role for the HIC1 gene in the pathogenesis of breast ductal carcinomas.

Asunto(s)

Neoplasias de la Mama/genética; Carcinoma Ductal de Mama/genética; Metilación de ADN; Regiones Promotoras Genéticas; Factores de Transcripción/genética; Deleción Cromosómica; Cromosomas Humanos Par 17/genética; Análisis Mutacional de ADN; ADN de Neoplasias/análisis; Proteínas de Unión al ADN; Femenino; Humanos; Factores de Transcripción de Tipo Kruppel; Repeticiones de Microsatélite

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Neoplasias de la Mama / Regiones Promotoras Genéticas / Carcinoma Ductal de Mama / Metilación de ADN Límite: Female / Humans Idioma: En Revista: Cancer Lett Año: 2005 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Irlanda

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