Hepatoprotective effect of lactic acid bacteria, inhibitors of beta-glucuronidase production against intestinal microflora.
Arch Pharm Res
; 28(3): 325-9, 2005 Mar.
Article
en En
| MEDLINE
| ID: mdl-15832821
The hepatoprotective activity of lactic acid bacteria (Lactobacillus brevis HY7401, Lactobacillus acidophilus CSG and Bifidobacterium longum HY8001), which inhibited beta-glucuronidase productivity of intestinal microflora, on t-BHP- or CCl4-induced hepatotoxicity of mice were evaluated. These oral administration of lactic acid bacteria lowered beta-glucuronidase production of intestinal microflora as well as Escherichia coli HGU-3. When lactic acid bacteria at a dose of 0.5 or 2 g (wet weight)/kg was orally administered on CCl4-induced liver injury in mice, these bacteria significantly inhibited the increase of plasma alanine transferase and aspartate transferase activities by 17-57% and 57-66% of the CCl4 control group, respectively. These lactic acid bacteria also showed the potent hepatoprotective effect against t-BHP-induced liver injury in mice. The inhibitory effects of these lactic acid bacteria were more potent than that of dimethyl diphenyl bicarboxylate (DDB), which have been used as a commercial hepatoprotective agent. Among these lactic acid bacteria, L. acidophilus CSG exhibited the most potent hepatoprotective effect. Based on these findings, we insist that an inhibitor of beta-glucuronidase production in intestine, such as lactic acid bacteria, may be hepatoprotective.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bifidobacterium
/
Ácido Láctico
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Glucuronidasa
/
Intestinos
/
Lactobacillus
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Arch Pharm Res
Año:
2005
Tipo del documento:
Article
Pais de publicación:
Corea del Sur