Osteoblastic proliferative activity of Epimedium brevicornum Maxim.
Phytomedicine
; 12(3): 189-93, 2005 Mar.
Article
en En
| MEDLINE
| ID: mdl-15830840
The effect of the extracts of Epimedium brevicornum Maxim. was investigated on proliferative activity in vitro. The osteoblast-like UMR106 cells was employed as an osteoblast model. The EtOH extract and the n-butanol fraction from the crude extract were found to show proliferation stimulating activity. Three flavonoid compounds (icariin, epimedin B and epimedin C) were isolated from this fraction by activity-guided assay, and the effects on cell proliferation were studied. Icariin produced the most significant promoting effect on the proliferation in osteoblast-like UMR106 cells. The results suggested that E. brevicornum Maxim. extracts might have potential activity against osteoporosis, and flavonoids such as icariin might be the active constituents stimulating osteoblasts.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteoblastos
/
Extractos Vegetales
/
Remodelación Ósea
/
Epimedium
/
Proliferación Celular
/
Fitoterapia
Límite:
Humans
Idioma:
En
Revista:
Phytomedicine
Asunto de la revista:
TERAPIAS COMPLEMENTARES
Año:
2005
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Alemania