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Micelles based on polyvinyl alcohol substituted with oleic acid for targeting of lipophilic drugs.
Luppi, B; Bigucci, F; Cerchiara, T; Andrisano, V; Pucci, V; Mandrioli, R; Zecchi, V.
Afiliación
  • Luppi B; Department of Pharmaceutical Sciences, Bologna University, Bologna, Italy. bluppi@biocfarm.unibo.it
Drug Deliv ; 12(1): 21-6, 2005.
Article en En | MEDLINE | ID: mdl-15801717
Polymeric micelles based on polyvinyl alcohol substituted with oleic acid were used as vehicles for progesterone and folic acid. The ability of this amphiphilic polymer to entrap lipophilic drugs and to generate stable micelles in aqueous neutral medium makes it a good candidate for drug delivery. The release of the loaded drugs in acidic environments represents another important property of these systems. Size of micelles, their stability, and their drug-loading capacity were evaluated, as well as the in vitro controlled-release profiles at pH 7.4 and 5.5.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcohol Polivinílico / Progesterona / Sistemas de Liberación de Medicamentos / Ácido Oléico / Ácido Fólico Idioma: En Revista: Drug Deliv Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2005 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcohol Polivinílico / Progesterona / Sistemas de Liberación de Medicamentos / Ácido Oléico / Ácido Fólico Idioma: En Revista: Drug Deliv Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2005 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido