Murine polyomavirus-VP1 virus-like particles immunize against some polyomavirus-induced tumours.
In Vivo
; 19(2): 323-6, 2005.
Article
en En
| MEDLINE
| ID: mdl-15796193
The ability of murine polyomavirus (MPyV)-VP1 virus-like particles (MPyV-VLPs) to immunize against MPyV tumour outgrowth was investigated. Non-immunized and mice immunized three times were challenged with MPyV or non-MPyV tumours and followed for tumour outgrowth. MPyV-VLP immunization abrogated outgrowth of some, but not all, tested MPyV tumours and delayed the outgrowth of a non-MPyV tumour to some extent. However, when mice were irradiated prior to tumour challenge to avoid an unspecific immune response, protection was MPyV-specific. In conclusion, VLP immunization for prevention of viral infection could also contribute to immune-protection against some tumours induced by the corresponding virus.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones Tumorales por Virus
/
Poliomavirus
/
Infecciones por Polyomavirus
/
Proteínas de la Cápside
/
Neoplasias Experimentales
Límite:
Animals
Idioma:
En
Revista:
In Vivo
Asunto de la revista:
NEOPLASIAS
Año:
2005
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Grecia