P-cadherin expression in glandular lesions of the uterine cervix detected by liquid-based cytology.

Longatto Filho, A; Albergaria, A; Paredes, J; Moreira, M A R; Milanezi, F; Schmitt, F C

Longatto Filho, A; Albergaria, A; Paredes, J; Moreira, M A R; Milanezi, F; Schmitt, F C.

Afiliación

Longatto Filho A; Pathology Division of Adolfo Lutz Institute, São Paulo, SP, Brazil.

Cytopathology ; 16(2): 88-93, 2005 Apr.

Article en En | MEDLINE | ID: mdl-15787651

RESUMEN

OBJECTIVE: To study P-cadherin aberrant expression as a possible marker for cervical adenocarcinomas in cytological samples. METHODS: We studied P-cadherin immunoexpression in liquid-based cervical cytology samples of biopsy-proven cervical lesions. RESULTS: We found a statistically significant correlation between P-cadherin expression and a cytological diagnosis of malignancy, either glandular or squamous (P < 0.0001). Twenty-two of 33 malignant cases showed P-cadherin membrane staining. None of the 30 benign cases tested showed membrane staining, but three of them displayed an aberrant nuclear P-cadherin expression. CONCLUSIONS: We concluded that P-cadherin can be used to discriminate between malignant and benign cervical cytological specimens, but not to discriminate glandular from squamous lesions.

Asunto(s)

Adenocarcinoma/metabolismo; Biomarcadores de Tumor/biosíntesis; Cadherinas/biosíntesis; Neoplasias del Cuello Uterino/metabolismo; Adenocarcinoma/patología; Femenino; Humanos; Inmunohistoquímica; Neoplasias del Cuello Uterino/patología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenocarcinoma / Biomarcadores de Tumor / Cadherinas / Neoplasias del Cuello Uterino Límite: Female / Humans Idioma: En Revista: Cytopathology Asunto de la revista: PATOLOGIA Año: 2005 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido

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