Nicotine induces conditioned place preferences over a large range of doses in rats.
Psychopharmacology (Berl)
; 178(4): 481-92, 2005 Apr.
Article
en En
| MEDLINE
| ID: mdl-15765262
RATIONALE: Conditioned place preference (CPP) procedures provide one measure of potential rewarding effects of abused drugs. Many attempts to induce CPP with nicotine have been unsuccessful. OBJECTIVES: To assess the influence of nicotine dose and stimulus assignment procedure on development of nicotine-induced CPP. METHODS: Initial preferences for one side of a two-compartment apparatus were first determined in Sprague-Dawley rats. In subsequent conditioning trials, the compartment paired with nicotine was the initially preferred side for half of the rats, and the initially non-preferred side for the other half. Rats received either an injection of nicotine (0.01-2 mg/kg SC) before being placed in one compartment (three trials) or saline before being placed in the other compartment (three trials). Control rats had saline injections associated with both compartments. A final test trial with no injection assessed final place preference. RESULTS: Significant CPP were induced by 0.1-1.4 mg/kg doses of nicotine. Nicotine-induced CPP were only apparent when nicotine was paired with the initially non-preferred side. Moreover, a very high dose of nicotine (2 mg/kg) induced conditioned place aversion when paired with the initially preferred side of the apparatus. CONCLUSIONS: Nicotine induced significant CPP across a wide range of doses, in accordance with its role as the primary addictive component of tobacco. Small preferences for one side of the apparatus played a major role in the development of nicotine-induced CPP. These findings suggest that biased procedures may be more suitable than unbiased procedures for evaluation of rewarding effects of nicotine using CPP paradigms.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Condicionamiento Operante
/
Relación Dosis-Respuesta a Droga
/
Nicotina
Tipo de estudio:
Evaluation_studies
Aspecto:
Patient_preference
Límite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Alemania