Autoantibodies in Type 1 diabetes.
Clin Chim Acta
; 354(1-2): 35-40, 2005 Apr.
Article
en En
| MEDLINE
| ID: mdl-15748597
BACKGROUND: Autoimmune diseases are associated with autoantibodies which recognise specific antigens. METHODS: Autoantibodies can be detected by various methods including immunofluorescence and radioimmunoassays using disease-specific radiolabelled recombinant autoantigens As recombinant assay have high-throughput potential, it is now even possible to screen whole populations. RESULTS: Diabetes-associated autoantibodies including autoantibodies to glutamic acid decarboxylase are valuable in disease classification and disease prediction. Some autoantibodies are more predictive of diabetes than others. CONCLUSIONS: Autoantibodies, and the antigens they recognise, are potentially valuable in the prediction and prevention respectively of type 1 diabetes as well as in the classification of autoimmune diabetes. Screening the general population for type 1 diabetes susceptibility is now feasible. Trials to prevent type 1 diabetes using disease-associated autoantigens are now in progress.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Diabetes Mellitus Tipo 1
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Clin Chim Acta
Año:
2005
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
Países Bajos