Efg1 involved in drug resistance by regulating the expression of ERG3 in Candida albicans.
Antimicrob Agents Chemother
; 49(3): 1213-5, 2005 Mar.
Article
en En
| MEDLINE
| ID: mdl-15728931
The ERG3 gene in Candida albicans was identified as a gene whose mRNA level was higher in the cph1/cph1 efg1/efg1 double mutant than in the wild-type cells. Further study showed that Efg1, but not Cph1, negatively regulated ERG3. Mutations in EFG1 consistently increased the susceptibility of the cells to antifungal agents.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxidorreductasas
/
Factores de Transcripción
/
Candida albicans
/
Proteínas Fúngicas
/
Regulación Fúngica de la Expresión Génica
/
Proteínas de Unión al ADN
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2005
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos