Alcohol-seeking behavior: the roles of the hypothalamic-pituitary-adrenal axis and the endogenous opioid system.
Alcohol Health Res World
; 22(3): 202-10, 1998.
Article
en En
| MEDLINE
| ID: mdl-15706797
Both the hormones of the hypothalamic-pituitary-adrenal (HPA) axis and the endogenous opioid system are activated in response to stress as well as after alcohol consumption, supporting the hypothesis that stress can influence both alcohol consumption and craving for alcohoL Activation of the HPA axis by stress or alcohol results in the production of glucocorticoid hormones, such as cortisol. Those hormones, in turn, are important for the release of the brain chemical dopamine in certain brain areas that are associated with the rewarding and reinforcing effects of alcohol and other drugs. Alcohol-induced release of certain endogenous opioids similarly results in dopamine release in those brain regions. Through this mechanism, both the HPA axis and the endogenous opioid system may influence alcohol consumption. Consequently, genetically determined differences in the activities of the HPA axis and endogenous opioid system may help determine a person's alcohol consumption level and vulnerability to alcoholism.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sistema Hipófiso-Suprarrenal
/
Consumo de Bebidas Alcohólicas
/
Conducta Adictiva
/
Péptidos Opioides
/
Sistema Hipotálamo-Hipofisario
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Alcohol Health Res World
Año:
1998
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Estados Unidos