[Retrospective dose estimation in remote period after exposure using different biological methods]. / Retrospektivnaia otsenka doz v otdalennyi postraditsionnyi period raznymi biologicheskimi metodami.
Radiats Biol Radioecol
; 44(6): 637-52, 2004.
Article
en Ru
| MEDLINE
| ID: mdl-15700803
Investigation of application of chromosome aberrations of lymphocytes in peripheral blood for biological dosimetry purposes in remote (up to 40 years) period after acute exposure to doses of 1 Gy and more was carried out. The comparative analysis of frequency of unstable and stable (using FISH and G-banding methods) aberrations was performed for 24 subjects accidentally exposed to radiation on nuclear submarines during 1961-1985. Statistically significant increasing of frequency of dicentrics and centric rings was determined in the exposed subjects in remote period after exposure to compare with controls. Their sum frequency in the exposed group varied depending on ARS heaviness from 0.1 to 1.0 aberrations per 100 cells. In control group it was from 0 to 0.2 correspondingly. Translocation frequency (complete + incomplete) fixed by FISH method (2, 4, and 12 chromosomes) varied within the limits of 0.2-16.0 for exposed subjects and 0.3-1.26 translocations per genome per 100 cells for controls. Some examined persons (5 subjects) exposed to accident in 1985 had results of analysis of unstable chromosome aberration in acute period after exposure that allow to estimate obtained doses by dicentrics frequency which having good correlation with ARS heaviness. Individual dosed using traslocation frequency were defined retrospectively in 11 from 21 exposed persons. They correlate with calculated physics doses and doses estimated by haematolotical parameters in acute period and also doses obtained by ESR spectroscopy of tooth enamel in remote period.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Radiometría
/
Aberraciones Cromosómicas
/
Liberación de Radiactividad Peligrosa
/
Exposición a Riesgos Ambientales
Límite:
Humans
Idioma:
Ru
Revista:
Radiats Biol Radioecol
Asunto de la revista:
GENETICA
/
MEDICINA NUCLEAR
Año:
2004
Tipo del documento:
Article
Pais de publicación:
Rusia