Local learning rules: predicted influence of dendritic location on synaptic modification in spike-timing-dependent plasticity.
Biol Cybern
; 92(2): 128-38, 2005 Feb.
Article
en En
| MEDLINE
| ID: mdl-15696313
Recent indirect experimental evidence suggests that synaptic plasticity changes along the dendrites of a neuron. Here we present a synaptic plasticity rule which is controlled by the properties of the pre- and postsynaptic signals. Using recorded membrane traces of back-propagating and dendritic spikes we demonstrate that LTP and LTD will depend specifically on the shape of the postsynaptic depolarization at a given dendritic site. We find that asymmetrical spike-timing-dependent plasticity (STDP) can be replaced by temporally symmetrical plasticity within physiologically relevant time windows if the postsynaptic depolarization rises shallow. Presynaptically the rule depends on the NMDA channel characteristic, and the model predicts that an increase in Mg(2+) will attenuate the STDP curve without changing its shape. Furthermore, the model suggests that the profile of LTD should be governed by the postsynaptic signal while that of LTP mainly depends on the presynaptic signal shape.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Potenciales de Acción
/
Transmisión Sináptica
/
Dendritas
/
Aprendizaje
/
Modelos Neurológicos
/
Plasticidad Neuronal
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Biol Cybern
Año:
2005
Tipo del documento:
Article
Pais de publicación:
Alemania