Taurolithocholate-induced inhibition of biliary lipid and protein excretion in the rat.
Biochim Biophys Acta
; 1125(1): 44-8, 1992 Apr 08.
Article
en En
| MEDLINE
| ID: mdl-1567906
Taurolithocholate (TLC), a natural bile salt, induces selective impairment on canalicular membrane of the hepatocyte, which seems to be a major determinant of its cholestatic effect in experimental animals. In order to extend existing studies about the effects of TLC on bile secretion, we examined in TLC-treated rats the biliary excretion of compounds that are transported to canalicular membrane via vesicles, such as lipids and proteins. The single intravenous injection of TLC (3 mumol/100 g body wt.) inhibited transiently the biliary bile salt excretion, while the biliary excretion of lipids (i.e., cholesterol and phospholipids) and proteins remained inhibited even though the biliary excretion and composition of bile salts were normalized. Under such a condition, TLC also inhibited the transcellular vesicular pathway to the exogenous protein horseradish peroxidase entry into bile, without altering the paracellular biliary access of the protein. The hepatic uptake of horseradish peroxidase was unaffected by TLC-treatment. The results indicate that TLC can inhibit the biliary excretion of compounds that reach the canaliculus via a vesicular pathway, such as lipids and proteins, by a mechanism not related to a defective bile salt excretion. Possible explanations for these findings are discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácido Taurolitocólico
/
Bilis
/
Proteínas
/
Metabolismo de los Lípidos
Límite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
1992
Tipo del documento:
Article
País de afiliación:
Argentina
Pais de publicación:
Países Bajos