RAD52 Y415X truncation polymorphism and epithelial ovarian cancer risk in Australian women.
Cancer Lett
; 218(2): 191-7, 2005 Feb 10.
Article
en En
| MEDLINE
| ID: mdl-15670896
The RAD52 gene is involved in the homologous recombination repair pathway and is a plausible candidate ovarian cancer predisposition gene. We undertook a case-control comparison of 508 epithelial ovarian cancer cases (91 low malignant potential and 417 invasive) and 298 healthy controls to assess the RAD52 Y415X polymorphism as a risk factor for epithelial ovarian cancer in Australian women. Heterozygote frequencies of 2.6 and 4% were observed among cases and controls, respectively. The risk estimate was 0.55 (95%CI 0.24-1.24), suggesting that the RAD52 Y415X polymorphism is not associated with epithelial ovarian cancer in Australian women.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Polimorfismo Genético
/
Neoplasias Glandulares y Epiteliales
/
Proteína Recombinante y Reparadora de ADN Rad52
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Cancer Lett
Año:
2005
Tipo del documento:
Article
País de afiliación:
Australia
Pais de publicación:
Irlanda