Force generation by dynamic microtubules.
Curr Opin Cell Biol
; 17(1): 67-74, 2005 Feb.
Article
en En
| MEDLINE
| ID: mdl-15661521
The assembly and disassembly of microtubules can generate pushing and pulling forces that, together with motor proteins, contribute to the correct positioning of chromosomes, mitotic spindles and nuclei in cells. In vitro experiments combined with modeling have shed light on the intrinsic capability of dynamic microtubules to generate force, and various observations of positioning processes in cells and model systems have shown how pushing and pulling forces are used in different situations. A sophisticated set of microtubule-end-binding proteins is responsible for steering dynamic microtubules toward their cellular target and regulating the pushing and/or pulling forces that are generated once contact is established.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Regulación Fúngica de la Expresión Génica
/
Microtúbulos
Idioma:
En
Revista:
Curr Opin Cell Biol
Año:
2005
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Reino Unido