Visual evoked cortical responses and electroretinograms following implantation of human fetal mesencephalon to the right caudate nucleus in Parkinson's disease.
J Neurol Sci
; 107(2): 183-90, 1992 Feb.
Article
en En
| MEDLINE
| ID: mdl-1564516
Pattern electroretinograms and visual evoked cortical responses following flash and checkerboard pattern reversal stimulation were performed in 7 patients with advanced Parkinson's disease before and after implantation of human fetal ventral mesencephalon to the head of the right caudate nucleus. Six to nine months following surgery there was bilateral enhancement of flash-evoked response amplitudes. Electroretinogram measurements were unchanged. Individual increases in amplitude and decreases in latency were seen following pattern stimulation which were not statistically significant. A relationship between change in dyskinesia, and change in checkerboard pattern stimulation amplitude at 2.4 cycles per degree suggests that amplitude effects at this stimulus frequency are mediated via altered dopaminergic receptor status in the grafted hemisphere. This may be relevant to the mechanisms leading to generalised clinical improvements following this grafting technique.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Mesencéfalo
/
Núcleo Caudado
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Trasplante de Tejido Encefálico
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Trasplante de Tejido Fetal
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Electrorretinografía
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Potenciales Evocados Visuales
Límite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Neurol Sci
Año:
1992
Tipo del documento:
Article
Pais de publicación:
Países Bajos