Sirolimus addition is beneficial for renal allograft dysfunction due to simultaneous acute rejection episode and calcineurin inhibitor nephrotoxicity.

Chang, H-R; Lee, M-H; Wen, M-C; Lian, J-D

Chang, H-R; Lee, M-H; Wen, M-C; Lian, J-D.

Afiliación

Chang HR; Division of Nephrology, Department of Internal Medicine, Chung-Shan Medical University, Taichung, Taiwan.

Transplant Proc ; 36(9): 2668-70, 2004 Nov.

Article en En | MEDLINE | ID: mdl-15621119

RESUMEN

We report a diabetic renal transplant recipient who experienced an episode of acute allograft rejection in the 6th month posttransplant when there was an attempt at steroid withdrawal. The acute rejection was steroid resistant. Furthermore calcineurin inhibitor nephrotoxicity was exacerbated by rescue therapy with tacrolimus conversion. The allograft dysfunction ultimately stabilized upon institution of sirolimus and minimization of tacrolimus.

Asunto(s)

Trasplante de Riñón/inmunología; Sirolimus/uso terapéutico; Tacrolimus/uso terapéutico; Adulto; Inhibidores de la Calcineurina; Ciclosporina/uso terapéutico; Nefropatías Diabéticas/cirugía; Humanos; Inmunosupresores/uso terapéutico; Fallo Renal Crónico/cirugía; Masculino; Reoperación; Resultado del Tratamiento

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / Tacrolimus / Sirolimus Límite: Adult / Humans / Male Idioma: En Revista: Transplant Proc Año: 2004 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos

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