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Comparison of the pharmacokinetics of lidamycin in mice determined by two methods.
Liu, You-ping; Li, Quan-sheng; Huang, Yu-rong; Liu, Chang-xiao.
Afiliación
  • Liu YP; National Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China.
Yao Xue Xue Bao ; 39(9): 695-9, 2004 Sep.
Article en En | MEDLINE | ID: mdl-15606016
AIM: To compare two methods, the total radioactivity assay (RA method) and the radioactivity assay after separation with high performance liquid chromatography (HPLC-RA method). METHODS: 125I-Lidamycin was prepared by Iodogen method and separated by size exclusive high performance liquid chromatography. The pharmacokinetic parameters of lidamycin were assayed by two methods after intravenous injection to mice at the dose of 100 microg x kg(-1), and compared by statistical analysis. RESULTS: The pharmacokinetic parameters (Vd, T1/2alpha, T1/2beta, K21, K10, K12, AUC and CL) showed significant difference between the two methods (P < 0.05). CONCLUSION: The HPLC-RA method was better than the RA method to determine unchanged 125I-lidamycin.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aminoglicósidos / Antibióticos Antineoplásicos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Yao Xue Xue Bao Año: 2004 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aminoglicósidos / Antibióticos Antineoplásicos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Yao Xue Xue Bao Año: 2004 Tipo del documento: Article País de afiliación: China Pais de publicación: China