Analysis of quasispecies in the viral 5' untranslated region of hepatitis C virus to evaluate ribavirin mutagenic effect in patients receiving ribavirin and interferon-alfa.
Eur J Clin Microbiol Infect Dis
; 23(12): 923-6, 2004 Dec.
Article
en En
| MEDLINE
| ID: mdl-15599656
In the study presented here the ribavirin mutagenic effect was investigated by analyzing quasispecies in the viral 5' untranslated region of hepatitis C virus in six patients with chronic infection who started interpheron-alpha and ribavirin therapy. A remarkable mutation rate during treatment was found in only one individual. This patient had a sustained response and harbored a type 3a virus strain. The different mutated clones in this patient demonstrated no apparent close relationship that could suggest lack of selection pressure by ribavirin. The mutations were located within the loops of subdomains IIIb and IIId of the internal ribosomal entry site. This is an interesting initial finding that needs to be substantiated in a larger trial.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ribavirina
/
Interferón-alfa
/
Hepacivirus
/
Hepatitis C Crónica
/
Regiones no Traducidas 5'
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Eur J Clin Microbiol Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Alemania