Evaluation of 99mTc-L-methionine brain SPECT for detection of recurrent brain tumor: a pilot study with radiological and pathological correlation.
Acta Radiol
; 45(6): 649-57, 2004 Oct.
Article
en En
| MEDLINE
| ID: mdl-15587424
PURPOSE: To evaluate technetium labeled L-methionine for imaging recurrent brain tumors. MATERIAL AND METHODS: Brain SPECT with 99mTc-L-methionine was performed to evaluate tumor viability in 42 patients with primary brain tumor. Findings of SPECT were correlated with radiological and histopathological findings as reference. RESULTS: 99mTc-L-methionine showed localized increased uptake in 40 patients with tumor recurrence, whereas 2 patients with post-radiation gliosis did not show tracer accumulation. A low differential uptake rate (DUR) 2.43 +/- 0.74 and methionine retention (MR) index 0.93 +/- 0.03 was seen in cases of post-radiation gliosis. A high DUR (36.20 +/- 10.31) and MR index (4.87 +/- 2.37) was seen in cases of recurrent tumor. Mean DUR in high-grade tumors (44.01 +/- 8.46) was significantly higher (P<0.001) than in low-grade tumors (30.42 +/- 7.38), and mean MR index in high-grade tumors (7.03 +/- 2.05) was significantly higher than in low-grade tumors (3.27 +/- 0.82) (P<0.001). CONCLUSION: 99mTc-L-methionine can be used as a SPECT tracer to differentiate tumor recurrence from post-radiation gliosis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
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Tomografía Computarizada de Emisión de Fotón Único
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Tecnecio
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Radiofármacos
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Metionina
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Recurrencia Local de Neoplasia
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Acta Radiol
Año:
2004
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Reino Unido