Surgical sepsis: dysregulation of immune function and therapeutic implications.
Surgeon
; 1(4): 187-206, 2003 Aug.
Article
en En
| MEDLINE
| ID: mdl-15570763
Sepsis is defined clinically as the systemic inflammatory response of the host to the documented systemic infection. The pathophysiological disturbance involves both the innate and adaptive immune systems encompassing cellular immunity, humoral components and the complement system. Dendritic cells (antigen-presenting cells) are key cells involved in the regulation of the immune response in sepsis, in particular in activating T cells and especially inducing the production and secretion of specific cytokines. These are the main mediators in establishing prominent disturbances of inflammation in patients with sepsis. The clinical features of the sepsis syndrome may vary from minor clinical disturbances to severe multiple organ failure and death of the host. Appropriate therapeutic strategies for patients with sepsis utilise conventional therapy and new novel forms of treatment, which are showing promise for the future.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Respuesta Inflamatoria Sistémica
/
Sepsis
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Surgeon
Año:
2003
Tipo del documento:
Article
Pais de publicación:
Reino Unido