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Ketamine disrupts frontal and hippocampal contribution to encoding and retrieval of episodic memory: an fMRI study.
Honey, G D; Honey, R A E; O'Loughlin, C; Sharar, S R; Kumaran, D; Suckling, J; Menon, D K; Sleator, C; Bullmore, E T; Fletcher, P C.
Afiliación
  • Honey GD; University of Cambridge, Department of Psychiatry, Cambridge, UK.
Cereb Cortex ; 15(6): 749-59, 2005 Jun.
Article en En | MEDLINE | ID: mdl-15537676
The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine produces episodic memory deficits. We used functional magnetic resonance imaging to characterize the effects of ketamine on frontal and hippocampal responses to memory encoding and retrieval in healthy volunteers using a double-blind, placebo-controlled, randomized, within-subjects comparison of two doses of intravenous ketamine. Dissociation of the effects of ketamine on encoding and retrieval processes was achieved using two study-test cycles: in the first, items were encoded prior to drug infusion and retrieval tested, during scanning, on drug; in the second, encoding was scanned on drug, and retrieval tested once ketamine plasma levels had declined. We additionally determined the interaction of ketamine with the depth of processing that occurred at encoding. A number of effects upon task-dependent activations were seen. Overall, our results suggest that left frontal activation is augmented by ketamine when elaborative semantic processing is required at encoding. In addition, successful encoding on ketamine is supplemented by additional non-verbal processing that is incidental to task demands. The effects of ketamine at retrieval are consistent with impaired access to accompanying contextual features of studied items. Our findings show that, even when overt behaviour is unimpaired, ketamine has an impact upon the recruitment of key regions in episodic memory task performance.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lóbulo Frontal / Hipocampo / Ketamina / Anestésicos Disociativos / Memoria Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2005 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lóbulo Frontal / Hipocampo / Ketamina / Anestésicos Disociativos / Memoria Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2005 Tipo del documento: Article Pais de publicación: Estados Unidos