Heat shock protein 60 autoimmunity and early lipid lesions in cholesterol-fed C57BL/6JBom mice during Chlamydia pneumoniae infection.
Atherosclerosis
; 177(2): 321-8, 2004 Dec.
Article
en En
| MEDLINE
| ID: mdl-15530906
Chronic Chlamydia pneumoniae infection and autoimmunity to heat shock protein 60 (Hsp60) have both been documented to be associated with atherosclerosis. Herein, we studied the effects of C. pneumoniae infection and a diet with a low-cholesterol supplement on the development of autoantibodies to mouse Hsp60 and early lipid lesions in the aortic valve of C57BL/6JBom mice. In addition, pulmonary infection was investigated. C57BL/6JBom mice were given one to three C. pneumoniae inoculations and fed either a regular diet or a diet enriched with 0.2% cholesterol. Autoantibody responses against mouse Hsp60 developed in both diet groups when the mice were infected with C. pneumoniae and in uninfected mice fed a cholesterol-enriched diet. C. pneumoniae infections increased subendothelial foam cell accumulation in mice on a 0.2% cholesterol-enriched diet (p = 0.022), without apparent hypercholesterolemia. These in vivo data suggest that autoantibodies against mouse Hsp60 develop as a consequence of cholesterol feeding and repeated C. pneumoniae infections. Further, infectious burden increased early lipid lesions in C57BL/6JBom mice fed a cholesterol-enriched diet.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Colesterol en la Dieta
/
Infecciones por Chlamydia
/
Autoinmunidad
/
Chlamydophila pneumoniae
/
Chaperonina 60
Límite:
Animals
Idioma:
En
Revista:
Atherosclerosis
Año:
2004
Tipo del documento:
Article
País de afiliación:
Finlandia
Pais de publicación:
Irlanda