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Genetic aspects of asthma.
Gao, P S; Huang, S K.
Afiliación
  • Gao PS; Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. pgao1@jhmi.edu
Panminerva Med ; 46(2): 121-34, 2004 Jun.
Article en En | MEDLINE | ID: mdl-15507881
Over the last few years, a significant progress has been made in understanding of the genetic basis of asthma. This has led to the identification of several chromosomal regions and loci showing linkage to and association with asthma and asthma-linked phenotypes. Recent positional cloning approaches have also been informative in identifying several strong candidate genes for asthma. The next challenge will involve validation of these findings and, importantly, identification of the functional basis in the pathophysiology of asthma. This review will describe the power of positional cloning for the identification of asthma genes, highlight the functional importance of the genetic variants, and address the gene-gene and gene-environment interactions that are pertinent to this challenging field.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Panminerva Med Año: 2004 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Italia
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Panminerva Med Año: 2004 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Italia