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Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor.
Takayanagi, R; Ohnaka, K; Sakai, Y; Nakao, R; Yanase, T; Haji, M; Inagami, T; Furuta, H; Gou, D F; Nakamuta, M.
Afiliación
  • Takayanagi R; Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Biochem Biophys Res Commun ; 183(2): 910-6, 1992 Mar 16.
Article en En | MEDLINE | ID: mdl-1550596
We isolated a cDNA encoding type-1 angiotensin II receptor from a human liver cDNA library. The cDNA had an open reading frame encoding a protein of 359 amino acid residues with a relative Mr of 41,060. The deduced amino acid sequence of the human angiotensin II (Ang II) receptor was 95.3% and 94.2% identical to those of bovine and rat type-1 Ang II receptors, respectively, and had a significant similarity with the G protein-coupled receptor. The rank order of the binding to the receptor expressed in COS-7 cells was Ang II greater than Ang III greater than Ang I. The expression of the Ang II receptor mRNA was detected in human liver, lung, adrenal and adrenocortical adenomas but not in adrenomedullary tumor, pheochromocytoma, by Northern blot analysis.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angiotensina II / Receptores de Angiotensina / Regulación Neoplásica de la Expresión Génica Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 1992 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angiotensina II / Receptores de Angiotensina / Regulación Neoplásica de la Expresión Génica Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 1992 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos